2015年科研成果展示

序号

批准单位

项目名称

负责人

等次

1

山东省人民政府

功能影像与分子靶向引导胸部肿瘤精准放疗

袁双虎

山东省科技

进步奖三等奖

2

山东省医学会

功能影像和疗效预测指导Ⅲ期非小细胞肺癌个体化放化疗的研究

黄  伟

山东医学科技奖科技创新成果奖二等奖

3

山东省医学会

has-mir-125a-5p等乳腺癌易感基因与山东汉族女性乳腺癌相关性的研究

刘  伟

山东医学科技奖科技创新成果奖三等奖

4

山东省医学会

Becker型肌营养不良致病突变基因检测及间充质干细胞干预的临床研究

崔  凯

山东医学科技奖科技创新成果奖三等奖

5

山东省医学会

FLT和FDG PET/CT对食管鳞癌靶区确定及手术治疗预后的对比研究

韩大力

山东医学科技奖科技创新成果奖三等奖

6

山东省医学会

胸部肿瘤个体化放疗减毒与增效研究

袁双虎

山东医学科技奖科技创新成果奖三等奖

7

山东省医学会

基于在线富集技术毛细管电泳在药物分析中的应用研究

刘玉国

山东医学科技奖科技创新成果奖三等奖

8

山东省医学会

HMGB1参与调控胃癌细胞凋亡及转移机制的研究

李增军

山东医学科技奖科技创新成果奖三等奖

9

山东省医学会

肿瘤护理指导手册

闫  荣

山东医学科技奖成果推广应用奖三等奖

10

山东省保健科技协会

Syk-Sp1-VEGF传导通路与胰腺癌淋巴管生成机制的研究

周武元

山东省保健科技协会

科学技术奖

二等奖

11

山东省保健科技协会

p-gp蛋白介导多药耐药状态功能显像的实验研究

崔永春

山东省保健科技协会

科学技术奖

二等奖

12

山东省保健科技协会

乳腺癌转移抑制基因的生物学功能及临床诊断应用研究

胡旭东

山东省保健科技协会

科学技术奖

三等奖

13

山东省保健科技协会

分子功能影像指导胶质瘤个体化治疗

李万湖

山东省保健科技协会

科学技术奖

三等奖

14

山东省医学科学院

参附注射液对心肺复苏后心功能的保护机制

郭志军

医科院科学技术成果奖一等奖

15

山东省医学科学院

肿瘤乏氧靶向多重自杀基因治疗的临床前研究

孙晓蓉

医科院科学技术成果奖二等奖

16

山东省医学科学院

乳腺癌发生发展及耐药的分子机制研究

李慧慧

医科院科学技术成果奖二等奖

17

山东省医学科学院

家族性腺瘤性息肉病家系成员cox-2、apc、β-catenin动态变化：5年随访分析

孙燕来

医科院科学技术成果奖二等奖

18

山东省医学科学院

分子功能影像指导恶性胶质瘤放疗的应用价值

李万湖

医科院科学技术成果奖三等奖

19

山东省医学科学院

乳腺癌转移的多层面分析及分子机制研究

于志勇

医科院科学技术成果奖三等奖

20

山东省医学科学院

功能影像对非小细胞肺癌个体化治疗的应用研究

谢  鹏

医科院科学技术成果奖三等奖

序号

科 室

作 者

论文题目

杂志名称

（时间、卷期、页码）

影响

因子

1

特一病区

于金明12T/13

温芝华1/13

(并列通讯)

Increased me-x-tabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

Oncogene

2015,34(10): 1241-1252

8.459

2

特一病区

于金明4T/4

蒋力扬1/4

Involved field irradiation for the treatment of esophageal cancer: Is it better than elective nodal irradiation?

Cancer Letter

2015,357(1):69-74

5.621

3

特一病区

于金明5T/5

滕菲菲1/5

Radiotherapy combined with immunecheckpoint blockade immunotherapy: Achievements and challenges.

Cancer Lett

2015,365(1):23-29

5.621

4

特一病区

孔  莉7T/8

于金明8T/8

朱  慧1/8

Increased serum carcinoembryonic antigen level can predict poor survival of patients with small cell lung cancer

Translational Research

2015,166:355-365

5.03

5

特一病区

于金明8T/8

滕菲菲1/8

Tumor-infiltrating lymphocytes, forkhead box P3, programmed death ligand-1, and cytotoxic T lymphocyte–associated antigen-4 ex-x-pressions before and after neoadjuvant chemoradiation in rectal cancer

Translational research

2015 ,166(6):721-732

5.03

6

放四病区

于金明10T/10

张  棚1/10

Early detection of radiation-induced heart disease using 99mTc-MIBI SPECT gated myocardial perfusion imaging in patients with oesophageal cancer during radiotherapy

Radiotherapy and Oncology

2015, 115(2): 171–178

4.363

7

特一病区

于金明8T/8

穆殿斌2T/8

滕菲菲1/8

孟祥姣3/8

Tumor infiltrating lymphocytes (TILs) before and after neoadjuvant chemoradiotherapy and its clinical utility for rectal cancer

Am J Cancer Res

2015,5(6):2064-2074

4.165

8

特一病区

于金明7T/7

赵  芬1/7

18F-Fluorothymidine PET-CT for Resected Malignant Gliomas before Radiotherapy: Tumor Extent According to Proliferative Activity Compared with MRI

Plos One

2015,10(3):e0118769

3.234

9

特一病区

于金明9T/9

孔  莉8T/9

井  旺1/9

朱  慧2/9

Feasibility of Elective Nodal Irradiation (ENI) and Involved Field Irradiation (IFI) in Radiotherapy for the Elderly Patients (Aged ≥70 Years) with Esophageal Squamous Cell Cancer: A Retrospective Analysis from a Single Institute

Plos One

2015,10（12）:0143007

3.234

10

特一病区

于金明9T/9

赵  芬1/9

FDG PET predicts pain response and local control in palliative radiotherapy with or without systemic treatment in patients with bone me-x-tastasis from non-small cell lung cancer

Clinical Lung Cancer

2015,16(6):111-119

3.104

11

放八病区

于金明11T/12袁双虎1/12

(并列通讯)

Concurrent involved-field radiotherapy and XELOX versus XELOX chemotherapy alone in gastric cancer patients with postoperative locoregional recurrence

Am J Clin Oncol.

2015,38(2):130-134

3.062

12

特一病区

于金明7T/7

陈大卫1/7

张  燕2/7

Sustained response of malignant pericardial effusion to intrapericardial bevacizumab in an advanced lung cancer patient: a case report and literature review

OncoTargets and Therapy

2015:8 2767–2770

2.311

13

特一病区

于金明4T/4

金  锋1/4

A spectrum of cutaneous toxicities from erlotinib may be a robust clinical marker for non-small-cell lung therapy: a case report and literature review

Onco Targets and Therapy 2015:8:943–946

2.311

14

物理室

于金明4T/4

尹  勇2/4

High-dose-rate Three-dimensional Conformal Radiotherapy Combined with Active Breathing Control for Stereotactic Body Radiotherapy of Early-stage Non-small-cell Lung Cancer

Technology in Cancer Research and Treatment

2015 ,14(6):677-82

1.73

15

放四病区

于金明9T/9

张  棚1/9

孟  雪2/9

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular me-x-tastasis: A case report and literature review

Oncology Letters

2015, 10(5): 3059-3063

1.554

16

放一病区

于金明6T/6

施鹏越1/6

孟  雪2/6

Association between serum tumor makers and me-x-tabolic tumor volume or total lesion glycolysis in patients with recurrent small cell lung cancer

Oncology Letters

2015,10:3123-3128

1.554

17

放三病区

于金明8T/8

徐  敏1/8

Different methods for target volume delineation of glandular breast tissue following breast-conserving surgery in breast cancer: A comparative study

Oncology letters

2015,10:625-630

1.554

18

特一病区

于金明6T/6

Inhibition of janus kinase 2 by compound AG490 suppresses the proliferation of MDA-MB-231 cells via up-regulating SARI (suppressor of AP-1, regulated by IFN)

Iranian Journal of Basic Medical Sciences

2015,18(6): 599-603

1.228

19

放十病区

于金明4T/4

孟祥姣1/4

Eczema as the first manifestation of a lung cancer

J Cancer Res Ther

2015 ,11(3):659

0.791

20

妇三病区

盛修贵3T/7

李兴兰1/7

尹月菊2/7

Distribution pattern of lymph node me-x-tastases and its implication in individualized radiotherapeutic clinical target volume delineation of regional lymph nodes in patients with stage IA to IIA cervical cancer

Radiation Oncology

2015,10:40

2.546

21

妇四病区

盛修贵3T/7

尹月菊1/7

李慧芹2/7

The Treatment of Pelvic Locoregional Recurrence of Cervical Cancer After Radical Surgery With Intensity-Modulated Radiation Therapy Compared With Conventional Radiotherapy: A Retrospective Study.

Int J Gynecol Cancer

2015,25(6):1058-65

1.958

22

妇三病区

盛修贵4T/4

李兴兰1/4

陈振宇2/4

Simultaneous modulated accelerated radiotherapy in cervical cancer with retroperitoneal lymph node me-x-tastasis after radical hysterectomy and pelvic lymphadenectomy

International Journal of Gynecological Cancer

2015, 5 (25) : 903-909

1.958

23

妇四病区

盛修贵9T/9

魏  萍1/9

(并列通讯)

Evaluation of prognostic factors for secondary cytoreductive surgery in Chinese patients with recurrent epithelial ovarian carcinoma

International Journal of Clinical and Experimental Medicine 2015,8(1):1066-1072

1.277

24

妇四病区

盛修贵6T/6

魏  萍1/6

(并列通讯)

Clinical observation study of conformal radiotherapy combined with topotecan chemotherapy treatment in patients with platinum- resistant recurrent ovarian cancer

Genetics and Molecular Research

2015,14 (2): 3833-3842

0.775

25

放六病区

李宝生7T/7

赵  倩1/7

Intratumoral Heterogeneity of Subcutaneous Nodules in a Never-Smoker Woman of Lung Squamous Cell Carcinoma Detected on 18F-Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography . A Case Report

Medicine

2015,94(21):e851

5.723

26

放六病区

李宝生8T/8

黄  伟1/8

Atlas of the thoracic lymph nodal delineation and recommendations for lymph nodal CTV of esophagealsquamous cell cancer in radiation therapy from China

Radiother Oncol.

2015, 116(1):100–106.

4.363

27

放六病区

李宝生6T/7

刘建国5T/7

王  娟1/7

李冬松2/7

(第二单位)

Gelatin tight-coated poly(lactide-co-glycolide) scaffolds incorporating BMP-2 for bone tissue engineering

Materials

2015,8:1009-1026

2.651

28

放六病区

李宝生8T/8

黄  伟1/8

刘  波2/8

The early predictive value of a decrease of me-x-tabolic tumor volume in repeated 18F-FDG PET/CT for recurrence of locally advanced non-small cell lung cancer with concurrent radiochemotherapy.

Eur J Radiol.

2015 Mar;84(3):482-8

2.369

29

放六病区

李宝生5T/5

董  玮1/5

Clinical significance of microRNA-24 ex-x-pression in esophageal squamous cell carcinoma.

Neoplasma

2015,62(2):250-8

1.865

30

放六病区

李宝生8T/8

王  峰1/8

Comparison of Gefitinib versus VMP in the combination with radiotherapy for multiple brain me-x-tastases from non-small cell lung cancer

Cell Biochem Biophys

2015,71(2):1261-5

1.68

31

放六病区

李宝生7T/13

栾祖鹏1/13

Efficacy of 3D conformal thoracic radiotherapy for extensive-stage small-cell lung cancer: A retrospective study

Experimental and Therapeutic Medicine

2015,10(2): 671-678

1.269

32

放六病区

李宝生7T/7

韩  丹1/7

Comparison of once daily radiotherapy to 60 Gy and twicedaily radiotherapy to 45 Gy for limited stage small-celllung cancer

Thoracic Cancer

2015,6(5):643-8

0.898

33

放六病区

李宝生3T/5

张媛媛1/5

(单位)

Magnetic resonance imaging for N staging in non-small cell lung cancer: a systematic review and me-x-ta-analysis

Thorac Cancer

2015,6(2):123-32

0.898

34

放六病区

李宝生8T/8

张  炜1/8

Prospective study of special stage II (T2b-3N0M0) non-small-cell lung cancer treated with hypofractionated-simultaneous integrated boost-intensity modulated radiation therapy

Journal of Cancer Research and Therapeutics

2015,11(2): 381-387

0.791

35

内一病区

王哲海9T/10

翟  侃10T/10

李慧慧1/10

Tumour Necrosis Factor-α Gene Polymorphism Is Associated with me-x-tastasis in Patients with Triple Negative Breast Cancer

Scientific Reports

2015,13(5):10244

5.578

36

内三病区

王哲海11T/12张  阳12T/12

唐  博10T/12

张  霞1/12

张  斌2/12

Mechanisms of Gefitinib-mediated reversal of tamoxifen resistance in MCF-7 breast cancer cells by inducing Era re-ex-x-pression

SCIENTIFIC REPORTS

2015,5:7835

5.578

37

内三病区

王哲海4T/4

石  焕1/4

郭  珺2/4

A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer

Drug Design, Development and Therapy

2015,9:4989–4996

3.028

38

内三病区

王哲海2T/10张倩倩1/10

Comparison of single-agent chemotherapy and targeted therapy to first-line treatment in patients aged 80 years and older with advanced non-small-cell lung cancer

Onco Targets and Therapy

2015:8 893-898

2.311

39

内三病区

王哲海2T/4

孙雯雯1/4

Factors Influencing the Attitudes of Chinese Cancer Patients and Their Families Toward the Disclosure of a Cancer Diagnosis

Journal of cancer education

2015,30(1):20-25

1.23

40

基础实验室

宋现让5T/5

葛胜光4T/5

李  龙1/5

All-graphene composite materials for signal amplification toward ultrasensitive electrochemical immunosensing of tumor marker

Biosens Bioelectron

2015,71:108-114

6.409

41

放一病区

王仁本2T/10

窦  雪1/10

The prognostic role of TCF4 ex-x-pression in locally advanced rectal cancer patients treated with neoadjuvant chemoradiotherapy

Cancer Biomarkers

2015,15(2):181-188

1.721

42

放二病区

于甬华2T/5

张  硕1/5

Radiotherapy in muscle-invasive bladder cancer: the latest research progress and clinical application

Am J Cancer Res

2015,5(2):854-868

4.165

43

放二病区

于甬华8T/8

张  永1/8

高  超2/8

A randomized phase II study of erlotinib plus nab- paclitaxel versus erlotinib alone as second-line therapy for Chinese patients with advanced EGFR wild-type non-small-cell lung cancer

Cancer Invest

2015,33（6）:241-5

2.218

44

放二病区

于甬华2T/5

张  硕1/5

张  永4/5

Diagnosis and treatment of accessory breast cancer in 11 patients

Oncol Lett

2015,10(3):1783-1788

1.554

45

放二病区

于甬华2T/6

张  永1/6

18FDG PETCT standardized uptake value for the prediction of radiation pneumonitis in patients with lung cancer receiving radiotherapy

Oncol Lett

2015,10(5):2909-2914

1.554

46

放二病区

于甬华3T/4

张  硕1/4

Results of multimodal treatment for desmoplastic small round cell tumor of the abdomen and pelvis

Int J Clin Exp Med

2015,8(6):9658-66

1.277

47

放二病区

于甬华4T/7

高  超1/7

张  永2/7

Postoperative recurrence solitary fibrous tumor of the pelvic with malignant transformation.

Int J Clin Exp Med

2015,8(9):16827-833

1.277

48

放三病区

李建彬2T/10

王金之1/10

Changes in tumour volume and motion during radiotherapy for thoracic oesophageal cancer

Radiotherapy and Oncology  

2015,114(2):201-205

4.363

49

放三病区

李建彬2T/7

邵  倩1/7

Clinical investigation into the initial diagnosis and treatment of 1,168 lung cancer patients

Oncology letters

2015,9: 563-568

1.554

50

放三病区

李建彬 2T/8

国  兵 1/8

Interobserver variability in the delineation of the tumour bed using seroma and surgical clips based on 4DCT scan for external-beam partial breast irradiation

Radiation oncology

2015,10:66

2.546

51

放三病区

李建彬2T/10段益利1/10

Comparison of primary tumour volumes delineated on

four-dimensional computed tomography maximum intensity projection and 18 F-fluorodeoxyglucose positron emission tomography computed tomography images of non-small cell lung cancer

Journal of Medical Imaging and Radiation Oncology 2015,59(5):623-630

1.109

52

放四病区

孟  雪10T/10

刘  静1/10

Exploring Spatial Overlap of High-Uptake Regions Derived From Dual Tracer Positron Emission Tomography-Computer Tomography Imaging Using 18F-Fluorodeoxyglucose and 18F-Fluorodeoxythymidine in Nonsmall Cell Lung Cancer Patients

Medicine

2015,94(17):e678

5.723

53

放四病区

孟  雪6T/6

高  昂1/6

王世江2/6

18F-FDG avid volumes on pre-radiotherapy FDG PET as boost target delineation in non-small cell lung cancer

International journal of clinical and experimental medicine

2015, 8(5): 7561–7568

1.277

54

放四病区

孟  雪9T/9

陈晓婷1/9

赵  新2/9

Proliferation PET image to characterize pathological spatial features in patients with non-small cell lung cancer: a pilot study

International journal of clinical and experimental medicine,

2015;8(6):9758-9764

1.277

55

放四病区

王之奇9T/9

王世江1/9

Ligand-conjugated pH-sensitive polymeric micelles for the targeted delivery of gefitinib in lung cancers

Rsc Advances

2015,5(89): 73184-73193

3.84

56

放四病区

张华琦7T/8

王世江1/8

Knockdown of PKM2 Enhances Radiosensitivity of Non-small cell Lung Cancer

Cell Biochemistry and Biophysics

2015,73(1): 21-26

1.68

57

放八病区

袁双虎10T/10

高  嵩1/10

A pilot study imaging integrin αvβ3 with RGD PET/CT in suspected lung cancer patients

Eur J Nucl Med Mol Imaging

2015,42(13):2029-2037

5.383

58

放八病区

袁双虎11T/11

魏玉春1/11

Noninvasive Evaluation of me-x-tabolic Tumor Volume in Lewis Lung Carcinoma Tumor-Bearing C57BL/6 Mice with Micro-PET and the Radiotracers 18F-Alfatide and 18F-FDG: A Comparative Analysis

PLOS ONE

2015;10(9):e0136195

3.234

59

放八病区

袁双虎8T/8

高  嵩1/8

Gastric me-x-tastasis from small cell lung cancer: A case report

World J Gastroenterol

2015,21(5):1684-1688

2.369

60

放十病区

邢力刚4T/8

孙晓蓉1/8

Visualizing the antivascular effect of bortezomib on the hypoxic tumor microenvironment

Oncotarget.

2015,6(33):34732-44

6.359

61

放十病区

邢力刚8T/9

赵汉玺1/9

谢  鹏2/9

A prospective phase II trial of EGCG in treatment of acute radiation-induced esophagitis for stage III lung cancer

Radiother Oncol.

2015,114(3):351-6

4.363

62

放十病区

邢力刚4T/4

于  洋1/4

Role of Gross Tumor Volume in the Prognosis of Non-Small Cell Lung Cancer Treated With 3D Conformal Radiotherapy: A me-x-ta-Analysis.

Clin Ther

2015,37(10):2256-66

2.731

63

放十病区

邢力刚7T/7

董鑫哲1/7

吴培培2/7

Intra-tumour18F-FDG uptake heterogeneity decreases the reliability on target volume definition with positron emission tomography/computed tomography imaging

Journal of Medical Imaging and Radiation Oncology

2015,59:338–345

1.109

64

特一病区

王兴莉3T/3

刘玉国1/3

A randomized Phase II clinical study of combining panitumumab and bevacizumab, plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) compared with FOLFIRI alone as second-line treatment for patients with me-x-tastatic colorectal cancer and KRAS mutation

Oncotargets and Therapy

2015，8: 1061-1068

2.311

65

外一病区

刘  凯7T/7

霍志军1/7

Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation.

Cancer Sci

2015,106(10):1429-37

3.523

66

外一病区

左文述3T/5

霍志军1/5

me-x-tastases of basal-like breast invasive ductal carcinoma to the endometrium: A case report and review of the literature

Thorac Cancer 2015,6(4):548-52

0.898

67

外一病区

于志勇6T/6

刘  琪1/6

Correlation Analysis of Hormone Receptors and the ex-x-pressions of HER-2 and Ki-67 in Breast Cancer

European journal of gynaecological oncology

2015;36(1):78-83

0.611

68

外一病区

于志勇7T/7

王新昭1/7

宋洪宽2/7

Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib

Oncol Rep

2015,33(2):526-532

2.301

69

外一病区

于志勇8T/8

王新昭1/8

Correlation between p53 and epidermal growth factor receptor ex-x-pression in breast cancer classification

Genet Mol Res

2015,14(2):4282-4290

0.775

70

外一病区

于志勇7T/7

刘  琪1/7

王新昭2/7

Effects of the ninein‑like protein centrosomal protein on breast cancer cell invasion and migration

Mol Med Rep

2015,12(2):1659-1664

1.554

71

外二病区

左文述3T/8

葛文凯1/8

Evaluation of hormone receptor, human epidermal growth factor receptor-2 and Ki-67 with core needle biopsy and neoadjuvant chemotherapy effects in breast cancer patients

Thoracic Cancer

2015,6:64–69

0.898

72

外三病区

王永胜2T/11

毕  祥1/11

李敏敏3/11

Validation of the Memorial Sloan Kettering Cancer Center nomogram for predicting non-sentinel lymph node me-x-tastasis in sentinel lymph node-positive breast-cancer patients.

OncoTargets and Therapy

2015, 8:487-493

2.311

73

外三病区

王永胜6T/6

曹晓珊1/6

Axillary and internal mammary sentinel lymph node biopsy in male breast cancer patients: case series and review

OncoTargets and Therapy

2015, 8:1499-1502.

2.311

74

外三病区

王永胜10T/10

丛斌斌1/10

曹晓珊2/10

Validation study of the modified injection technique for internal mammary sentinel lymph node biopsy in breast cancer

OncoTargets and Therapy

2015, 8: 2705–2708

2.311

75

外三病区

王永胜2T/5

曹晓珊1/5

Study of internal mammary sentinel lymph node biopsy in breast cancer patients after neoadjuvant chemotherapy

OncoTargets and Therapy

2015, 8: 2873–2874

2.311

76

外三病区

王永胜10T/10

孙  晓1/10

李  浩2/10

Sentinel lymph node biopsy in patients with breast ductal carcinoma in situ – Chinese experience

Oncol Lett

2015, 10(3): 1932-1938

1.554

77

外四病区

郭洪亮7T/8

(并列通讯)

ASPP2 enhances Oxaliplatin (L-OHP)-induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy

Journal of Cellular and Molecular Medicine

2015，19(3): 535-543

4.014

78

外四病区

李增军2T/9

王海鹏1/9

Relationship between high-mobility group box 1 overex-x-pression in ovarian cancer tissue and serum： a me-x-ta-analysis

Oncotargets and therapy 2015,8:3523-3531

2.311

79

外四病区

郭洪亮9T/11

(并列通讯1/4)

Mitochondrial DNA D-loop AG/TC transition mutation in cortical neurons of mice after long-term exposure to nucleoside analogues

Journal of NeuroVirology

2015,21:500-507

2.595

80

外四病区

郭洪亮5T/5

孙燕来1/5

(并列通讯、第一)

Gallbladder perforation: a rare complication of postoperative chemotherapy of gastric cancer.

World J Surg Oncol

2015,13:245

1.408

81

外四病区

孙燕来3T/4

徐忠法4T/4

（第二单位）

Multiple cutaneous and intestinal me-x-tastases in lung cancer: A case report.

Oncol Lett

2015,9 (4) :1541-1544

1.554

82

外四病区

徐忠法1T/9

（非唯一通讯）

A novel spherical magnetic compression device for colorectal anastomosis in a Swine model.

J Laparoendosc Adv Surg Tech

2015,25(4):323-9

1.335

83

外四病区

郭洪亮6T/6

柴  杰1/6

MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase

Tumor Biol

2015,36:1313–1321

3.611

84

外四病区

郭洪亮7T/8

张宗利8T/8

柴  杰1/8

MicroRNA-494 Sensitizes Colon Cancer Cells to Fluorouracil Through Regulation of DPYD

International Union of Biochemistry and Molecular Biology

2015,3:191–201

3.143

85

外四病区

管  杰10T/10

张  毅1/10

宋希林2/10

RLIP76 blockade by siRNA Inhibits proliferation，enhances apoptosis，and suppresses invasion in HT29 colon cancer cells

Cell biochem Biophys 2015,71:579-585

1.68

86

外五病区

李道堂3T/3

赵晓明1/3

Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis

Mol Cell Biochem

2015,400:1-7

2.393

87

外五病区

李道堂5T/5

赵晓明1/5

The Association between Preoperative Serum C-Reactive Protein and Hepatocellular Carcinoma Recurrence in Patients with Chronic Hepatitis B Virus (HBV) Infection—A Retrospective Study

Plos One

2015,10(1):e0116909

3.234

88

外五病区

黄承锁5T/5

刘曙光1/5

The Clinical Research of Serum VEGF, TGF-β1, and Endostatin in Non-small Cell Lung Cancer

Cell Biochemistry and Biophysics

2015,72:165-169

1.68

89

外七病区

杨明山2T/4

孙保勇1/4

The microRNA-217 functions as a tumor suppressor  and is frequently downregulated in human  osteosarcoma

Biomedicine & Pharmacotherapy

2015,71:58–63

2.023

90

外七病区

孙保勇1T/4

Identifications of genetic differences between me-x-tastatic and non-me-x-tastatic osteosarcoma samples based on bioinformatics analysis

Med Oncol

2015,32(5):153

2.634

91

外七病区

李  胜5T/5

佟  峰4T/5

王振丹1/5

Prognostic value of circulating tumor cells in patients with squamous cell carcinoma of the head and neck:a systematic reciew and me-x-ta-analysis

Medical Oncology

2015,32(5):164

2.634

92

外七病区

李  胜9T/9

靳  松1/9

Screening analysis of candidate gene mutations in a kindred

with polycystic liver disease

World J Gastroenterol

2015,21(8): 2343-2351

2.369

93

外七病区

李  胜9T/9

佟  峰8T/9

李  庞1/9

Transplantation of human umbilical cord-derived mesenchymalstems cells for the treatment of Becker muscular dystrophy in affected pedigree members

International Journal Of Molecular Medicine

2015,35:1051-1057

2.088

94

外七病区

张  波3T/6

王振丹1/6

Hemangioendothelioma arising from the spleen: A case report and literature review

Oncology Letters

2015,9(1): 209-212

1.554

95

外七病区

石学涛6T/7

周武元1/7

(并列通讯)

TCM matrine inducescell arrest and apoptosis with recovery ex-x-pression of the hepato-specific miR122a in human hepatocellular carcinomaHep G2cell line

International Journal of Clinical and Experimental Medicine

2015,8(6):9004-9012

1.277

96

外八病区

马  恒4T/4

刘  凯1/4

宋希林2/4

Overex-x-pression of FGFR2 contributes to inherent resistance to MET inhibitors in MET-amplified patient-derived gastric cancer xenografts

Oncol Lett

2015,10 (4): 2003-2008

1.554

97

外八病区

霍志军8T/8

刘  凯1/8

Hyaluronic acid-tagged silica nanoparticles in colon cancer therapy: therapeutic efficacy evaluation

Int J Nanomedicine

2015,10:6445-6454

4.383

98

外九病区

宋金龙5/5T

邵文博1/5

The hepatitis B virus reactivation after transarterial chemoembolization in Chinese hepatocellular carcinoma patients with low serum hepatitis B virus Dna level

Therapeutics and Clinical Risk Management

2015,11:1367–1370

1.469

99

外九病区

宋金龙6T/7

马双双1/7

卜文哲2/7

Radiotherapy treatment of large esophageal leiomyosarcoma: A case report

Oncology Letters  

2015,9:2422-2424

1.554

100

外十病区

刘吉兵1T/6

miR-1285-3p acts as a potential tumor suppressor miRNA via downregulating JUN ex-x-pression in  Hepatocellular Carcinoma

Tumor Biol

2015,36:219-225

3.611

101

外十病区

谢印法6T/6

吴会勇1/6

Transcatheter arterial chemoembolization (TACE) for lymph node me-x-tastases in patients with hepatocellular carcinoma

J Surg Oncol

2015,112(4):372-6

3.244

102

外十病区

胡旭东2T/6

王小玥1/6

Comparison of magnetic resonance spectroscopy and positron emission tomography in detection of tumor recurrence in posttreatment of glioma:A diagnostic neta-analysis

Asia-Pacific Journal of Clinical Oncology

2015,11（2）:97-105

1.542

103

外十病区

谢印法5T/5

谭学芬1/5

Therapeutic value of transcatheter arterial chemoembolization combined with portal vein embolization for primary hepatocellular carcinoma with portal vein tumor thrombus: A pilot study

Asia Pac J Clin Oncol

2015,11(3):6-12

1.542

104

外十病区

谢印法6T/6

吴会勇1/6

Pure transcatheter arterial chemoembolization therapy for intrahepatic tumors causes a shrink in pulmonary me-x-tastases of hepatocellular carcinoma

Int J Clin Exp Med

2015,8(1):1035-42

1.277

105

外十一病区

陈万军3T/9

王  亮1/9

Non-Functional Parathyroid Carcinoma: A Case Report and Review of the Literature

Cancer Biology & Therapy

2015,16(11):1569-76

3.072

106

外十一病区

王世江8T/8

王之奇1/8

A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy

J Nanobiotechnology

2015,13: 63

4.115

107

外十二病区

杨明山7T/7

李彦良1/7

si-RNA-Mediated Knockdown of PDLIM5 Suppresses Gastric Cancer Cell Proliferation in Vitro

Chem Biol Drug Des

2015,85:447–453

2.485

108

外十三病区

陶荣杰5T/5

赵海涛1/5

Pemetrexed plus rituximab as second-line treatment for primary central nervous system lymphoma

Med Oncol

2015,32(1):351

2.634

109

外十三病区

陶荣杰7T/7

Stripping surgery in facial nerve schwannomas with favorable facial nerve function

American Journal of Otolaryngology

2015，36(4): 513-516

0.984

110

麻醉科

王凯国7T/7

李  浩1/7

Effects of epidural analgesia with different concentrations of bupivacaine plus fentanyl on pain in patients undergoing thoracic surgery

Int J Clin Exp Med

2015,8(8):14123-6

1.277

111

内一病区

张  丽15T/15

吕宝玉1/15

CXCR4 Signaling Induced Epithelial-Mesenchymal Transition by PI3K/AKT and ERK Pathways in Glioblastoma

Mol Neurobiol

2015,52(3):1263-8

5.137

112

内一病区

张  述14T/16叶启农16T/16

徐小杰15T/16

冯莹莹1/16

李  玲2/16

张晓梅3/16

Hematopoietic pre-B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion

Cancer Sci

2015,106:1313–1322

3.523

113

内二病区

郭其森8T/8

王丽杰1/8

Association Between Chronic Respiratory Diseases and Helicobacter pylori:A me-x-ta-Analysis

Arch Bronconeumol  

2015,51(6):273-278

1.823

114

内三病区

刘  杰10T/10

宋  宝9T/10

程森森1/10

李建中2/10

刘文建3/10

LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: a case-control study

BMC Cancer

2015,15:480

3.362

115

内三病区

刘  杰11T/11

程森森1/11

邵珠林2/11

刘秀春3/11

Interleukin 17A Polymorphism Elevates Gene ex-x-pression and Is Associated with Increased Risk of Nonsmall Cell Lung Cancer

DNA Cell Biol

2015 34(1):63-68

2.055

116

内三病区

刘  杰5T/5

马  原1/5

孙菊杰2/5

Follicular dendritic cell sarcoma: two rare cases and a brief review of the literature.

Onco Targets Ther

2015,8:1823-1830

2.311

117

内三病区

刘  杰9T/9

马  原1/9

刘秀春2/9

朱井研3/9

Polymorphismsof co-inhibitoryMolecules  (CTLA-4/ PD-1/ PD-L1) and the riskof non-small cell lung cancer in a Chinese population

Int J Clin Exp Med

2015,8(9):16585-16591

1.277

118

内三病区

刘  杰8T/8

马  原1/8

孙  磊2/8

刘利妍3/9

Phase II clinical trial of palonosetron combined with tropisetron in preventing chemotherapy-induced nausea and vomiting.                                                    

Int J Clin Exp Med

2015,8(5):7989-7994

1.277

119

内五病区

时圣彬3T/5

田  静1/5

Cetuximab Plus Pemetrexed as second-line therapy for fluorouracil-based pre-treated me-x-tastatic esophageal squamous cell carcinoma

Cancer Chemother Pharmacol

2015,76:829-834

2.769

120

内六病区

任瑞美2T/7

柳善刚1/7

Diffusion-weighted imaging in assessing pathological response of tumor in breast cancer subtype to neoadjuvant chemotherapy

J Magn Reson Imaging

2015,42(3):779-787

3.21

121

内六病区

任瑞美8T/8

柳善刚1/8

Diagnostic Accuracy of MRI-guided Percutaneous Transthoracic Needle Biopsy of Solitary Pulmonary Nodules

Cardiovasc Intervent Radio

2015,38(2):416-421

2.071

122

内六病区

刘增军2T/8

Risk patterns of subsequent primary cancers following esophagectomy in early-stage thoracic esophageal squamous cell cancer patients

Tumori

2015,101(3):328-33

1.269

123

内八病区

周海燕2T/2

Molecularly targeted gemcitabine-loaded nanoparticulate system

towards the treatment of EGFR overexpressing lung cancer

Biomedicine & Pharmacotherapy

2015,70:123-128

2.023

124

内九病区

石  焕6T/6

Potential therapeutic strategy for gastric cancer peritoneal me-x-tastasis by NKG2D ligands-specific T cells

OncoTargets and Therapy 2015,8:3095–3104

2.311

125

内十病区

任国华7T/7

（并列通讯）

Effect of siRNA on Wisp-1 gene ex-x-pression, proliferation, migration and adhesion of mouse hepatocellular carcinoma cells

Asian Pacific Journal of Tropical Medicine

2015,8(10): 821–828

1.062

126

妇一病区

李庆水6T/6

蒋  胜1/6

me-x-tastasis of a cervical carcinoma to the clitoris

Journal of Obstetrics and Gynaecology

2015,35(2):213-214

0.551

127

妇三病区

刘乃富2T/2

陈  芳1/2

A 10‑gene ex-x-pression signature of Notch pathway predicts recurrence in ovarian carcinoma

Oncology letters

2015,10(3):1704-1708

1.554

128

影像科

黄  勇3T/3

戚元刚1/3

Analysis of computed tomography and pathological observations of non-Hodgkin lymphomas with peritoneal, omental and mesenteric involvement

Experimental And Therapeutic Medicine

2015,9:891-894

1.269

129

影像科

孙晓蓉2T/4

孙  露1/4

The role of (18)F-FDG PET/CT imaging in patient with malignant PEComa treated with mTOR inhibitor

Onco Targets Ther.

2015,8:1967-1970

2.311

130

物理室

卢  洁4T/9

张桂芳1/9

韩大力2/9

Gradient-based delineation of the primary GTV on FLT PET in squamous cell cancer of the thoracic esophagus and impact on radiotherapy planning

Radiation Oncology

2015,10(1):11

2.546

131

特检科

谢  丽2T /4

赵月环4T/4

郭  伟1/4

mRNA and microRNA ex-x-pression profiles of radioresistant NCI‑H520 non‑small cell lung cancer cells

Molecular Medicine Reports

2015,12: 1857-1867

1.554

132

特检科

赵月环6T/6

纪岩磊1/6

The clinical analysis of acute pancreatitis in colorectal cancer patients undergoing chemotherapy after operation

OncoTargets and Therapy

2015,8:2527-2533

2.311

133

教育科

崔永春4T/4

miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells

Biochemical and Biophysical Research Communications

2015,460(3):806-812

2.297

134

内三病区

王哲海1T/1

Selection of chemotherapy for non-small cell lung cancer is facilitated by new therapeutic strategies

Int J Clin Exp Med

2014,7(11):3833-3842

1.277

135

放八病区

赵  伟1T/12

Primary clear cell carcinoma of nasal cavity: report of six cases and review of literature

Int J Clin Exp Med

2014,7(12):5469-5476

1.277

136

外九病区

宋金龙6T/7

李金鹏1/7

Efficacy of Sorafenib for Advanced Hepatocellular Carcinoma and Prognostic Factors

Hepato-Gastroenterology

2014,61(132):954-957

0.928

137

检验科

周长春9T/10

(并列通讯)

The ALDH7A1 genetic polymorphisms contribute to development of esophageal squamous cell carcinoma

Tumor Biol

2014,35:12665-12670

3.611

138

内二病区

朱栋元1/7

Twist1 correlates with poor differentiation and progression in gastric adenocarcinoma via elevation of FGFR2 ex-x-pression

World J Gastroenterology

2014,20(48):18306-18315

2.36

序号

专利类型

专利名称

专利号 / 授权时间

发明人

1

发明专利

一种腹可安片的制备方法及其在制备抑制小鼠淋巴瘤细胞YAC-1细胞增殖药物中的应用

ZL2013 1 0659043.6、2015年06月10日

从  宁  邵文博  解  莹   李忠民

2

发明专利

一种益康补元片的制备方法及其在抑制小鼠淋巴瘤细胞L5178Y细胞增殖药物中的应用

ZL2013 1 0669829.6、2015年06月24日

邵文博  从  宁

3

发明专利

一种毛莲菜提取物的制备方法及其应用

ZL2013 1 0525676.8、2015年09月02日

孙燕来  张  毅  李  焱   李健宁

4

发明专利

一种齿缘草提取物的制备方法及其应用

ZL2013 1 0525327.6、2015年09月02日

张  毅  孙燕来  李  焱   李健宁

5

实用新型专利

一种引流管套组

ZL2014 2 0576660.X、2015年03月04日

李增军  张西坤

6

实用新型专利

悬挂式吸痰管道冲洗装置

ZL2014 2 0652494.7、2015年03月18日

韩静静  杨爱菊  于素娟   李  静   孙  兰

7

实用新型专利

双螺旋胃管固定贴

ZL2014 2 0692650.2、2015年04月08日

薛洪范  于素娟  葛洪霞   王  可   赵  英

刘玲玲  纪祥菊  毛会清      

8

实用新型专利

一种肿瘤放射皮肤反应的氧疗装置

ZL2015 2 0077938.3、2015年09月09日

朱昆莉  焦玉红  王仁本   朱  慧